At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide. Objective / Purpose: As a Computational Chemistry Leader, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientists, Structural Biologists, Pharmacologists, and Biologists to provide computational expertise to advance drug discovery projects. Contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics. Implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts. Accountabilities: Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment. Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success. Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects. Build and develop a strong team of Computational Chemists to high productivity levels. Demonstrate leadership and enterprise thinking in managing multi-disciplinary teams. DIMENSIONS AND ASPECTS: Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis. Significant industry experience contributing as a Computational Chemist on drug discovery projects. Strong impact in progressing Discovery Projects from Hits to Clinical Leads. Extensive knowledge & experience in using a variety of tools for Hit ID. Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints. Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery. Proficiency with state-of-the-art Computational Chemistry software. Network with renowned researchers in computational chemistry/AI. EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: PhD degree in a relevant scientific discipline. 6+ years of industry (pharma/biotech) drug discovery experience required. Takeda Compensation and Benefits Summary We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. For Location: Boston, MA U.S. Base Salary Range: 149,100.00 - 234,300.00 The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. EEO Statement Takeda is proud of its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law. Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt: Yes #J-18808-Ljbffr Takeda Pharmaceuticals
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